2 types of solutions to decline according to the level of project development:
  • The service delivery
  • The research project (CIR eligible)

Puce site

OUR SERVICES
ACTIVITY ASSAY
  • New methods of enzymatic avtivity development 
  • Simplification of assay methods
  • Measure of enzymatic activity on complex formulation
  • Enzymatic synthesis of oligosaccharides
ENZYMATIC ENGINEERING
  • Enzymatic target identification for using in green chemistry   
  • Biodiversity screenning  (Sourcing)
  • Cloning, production and caracterization of enzyme 
  • Enzymatic optimisation by molecular engineering
3D MODELING
  •  Modelling, docking and molecular simulation
  • Molecular dynamics
  • Statistical study for the engineering of proteins
Puce siteAPPLICATION FIELDS

Enzymes are key elements in most biological mechanisms and are alternatives for the transition from synthetic to green chemistry. D-Zyme's service innovation is based on cutting-edge expertise in enzymatic engineering and enzymology that can be applied to different fields:

HEALTH
GREEN CHEMISTRY
BIO-REFINERY
FOOD and FEED
COSMETICS
BIOMATERIALS
Puce siteSOME OF OUR PARTNERS

ACADEMIC PARTNERS Puce site

Puce sitePUBLICATIONS (most recent...) 

Multivalent Thiosialosides and Their Synergistic Interaction with Pathogenic Sialidases. Brissonnet Y, Assailly C, Saumonneau A, Bouckaert J, Maillasson M, Petitot C, Roubinet B, Didak B, Landemarre L, Bridot C, Blossey R, Deniaud D, Yan X, Bernard J, Tellier C, Grandjean C, Daligault F, Gouin SG. Chemistry. 2019 Feb 11;25(9):2358-2365. 

Magnetic Nanoparticles Coated with Thiomannosides or  Iminosugars to Switch and Recycle Galactosidase Activity. Alvarez-Dorta D, Brissonnet Y, Saumonneau A, Deniaud D, Bernard J, Yan X, Tellier C, Daligault F, Gouin S. Chemistry Select, 2017Oct 2(29).

Design of an α-L-transfucosidase for the synthesis of fucosylated HMOs. Saumonneau A, Champion E, Peltier-Pain P, Molnar-Gabor D, Hendrickx J, Tran V, Hederos M, Dekany G, Tellier C. Glycobiology. 2015 Nov 17. pii: cwv099.

Enhancing the chemoenzymatic synthesis of arabinosylated xylo-oligosaccharides by GH51 α-l-arabinofuranosidase. Arab-Jaziri F, Bissaro B, Tellier C, Dion M, Fauré R, O'Donohue MJ. Carbohydr Res. 2015 Jan 12;401:64-72.

Semi-rational approach for converting a GH36 α-glycosidase into an α-transglycosidase. Teze D, Daligault F, Ferrières V, Sanejouand YH, Tellier C. Glycobiology. 2014 Nov 13

De novo design of a trans-β-N-acetylglucosaminidase activity from a GH1 β-glycosidase by mechanism engineering. André-Miral C, Koné FM, Solleux C, Grandjean C, Dion M, Tran V, Tellier C. Glycobiology. 2014 Nov 4.

Semi-rational approach for converting a GH1 β-glycosidase into a β-transglycosidase. Teze D, Hendrickx J, Czjzek M, Ropartz D, Sanejouand YH, Tran V, Tellier C, Dion M. Protein Eng Des Sel. 2014 Jan;27(1):13-9.

Engineering transglycosidase activity into a GH51 α-l-arabinofuranosidase. Arab-Jaziri F, Bissaro B, Dion M, Saurel O, Harrison D, Ferreira F, Milon A, Tellier C, Fauré R, O'Donohue MJ. N Biotechnol. 2013 Jun 25;30(5):536-44.

Alkoxyamino glycoside acceptors for the regioselective synthesis of oligosaccharides using glycosynthases and transglycosidases. Teze D, Dion M, Daligault F, Tran V, André-Miral C, Tellier C. Bioorg Med Chem Lett. 2013 Jan 15;23(2):448-51.

Rational design of a GH1 beta-glycosidase to prevent self-condensation during the transglycosylation reaction. Tran V, Hoffmann L, Rabiller C, Tellier C, Dion M. Protein Eng Des Sel. 2010 Jan;23(1):43-9.

Engineering of glucoside acceptors for the regioselective synthesis of beta-(1->3)-disaccharides with glycosynthases. Marton Z, Tran V, Tellier C, Dion M, Drone J, Rabiller C. Carbohydr Res. 2008 Nov 24;343(17):2939-46.